leptin

Obese people have much higher concentrations of circulating leptin than the general population, and they can become leptin resistant.

Actually, too much insulin signaling interferes with leptin signaling, making you respond less to leptin signaling.

The low fat diet advice has done horrendous things to people's metabolisms, leaving people insulin and leptin resistant.

Effects of short-term carbohydrate or fat overfeeding on energy expenditure and plasma leptin concentrations in healthy female subjects.

Among other things, it talks about how gluten might interfere with leptin (the hormone that makes us feel full).

Lyle McDonald wrote a great series of articles on why diets fail (hint: it's a hormone called leptin) [1].

And assuming the butter and mayo aren't packed with extra sweetener or leptin suppressors, they're not a big deal.

This makes leptin signaling less effective and makes you want to eat more in spite of having enough body fat.

His body is demanding increased caloric intake (via insulin, leptin, and ghrelin) to maintain fat stores.

So what's the best way to acutely raise leptin levels when they're depressed from caloric restriction?

If you are feeling hungry all the time, it is because you are leptin resistant.

Things like sweet potatoes and pasta will fill you up and replete your leptin levels.

Leptin's effects on the hunger-controlling hypothalamus explain why you may obsess over calorie-dense junk foods when you diet.

Leptin signals fat cells to store energy as fat, and if it doesn't do that then you wont get fatter.

Leptin is the satiety hormone that is released by your fat cells.