pharmacological

That you were able to learn on your own doesn't mean others can without pharmacological help.

There seems to be a big resistance to a pharmacological solution to mental health problems on HN.

Inositol but it was a huge amount: more than 20mg/day, which is most definitely a pharmacological quantity.

Is anyone aware of a similar sourced survey of the literature for pharmacological cognitive enhancers i.e.

There are decades of successful pharmacological research based on receptor targets, signaling pathways, etc.

It's the sort of framing that is much preferred by the pharmacological industry, because it suggests that the nature of the problem is well understood and can be directly addressed with their products.

When compared to psychological or pharmacological therapies, exercise appears to be no more effective, though this conclusion is based on a few small trials.

There are papers that compare specific classes of new substances or techniques, but no comprehensive treatment of the idea of cumulative/permanent pharmacological brain enhancement yet.

I have no reason to believe that the pharmacological drug industry is fundamentally more honest.

Even the studies you cited only show minimal plaque volume reduction (so small it's questionable if it helps at all) and only with intensive pharmacological therapy.

Even with pharmacological intervention, reducing plaque size is really tough.

They are great in conjunction with standard pharmacological and therapeutic approaches, but might end up pushing someone already on the brink further into the abyss of depression.

It does say "When compared to psychological or pharmacological therapies, exercise appears to be no more effective, though this conclusion is based on a few small trials.", in which case, can anything be recommended?

From the paper's abstract (published by Nature Medicine, 08 December 2014): "These preclinical studies suggest that, so far, this unimolecular, polypharmaceutical strategy has potential to be the most effective pharmacological approach to reversing obesity and related metabolic disorders."

Others might not share my misgivings but I would only be willing being prescribed a psychoactive drug by a specialist (psychologist/psychiatrist) after a thorough evaluation and non-pharmacological therapy first, and even then very conservatively and after an explanation more objective than "you have a chemical imbalance in your brain" (which chemicals?