reuptake

It's more clear with drugs that create physical dependence, like opioids or dopamine reuptake inhibitors (cocaine, amphetamines).

An artificial serotonin reuptake inhibitor would just allow the serotonin-like activity to more active in the model.

> that doesn't mean that drugs which decrease reuptake/increase (by proxy) serotonin levels won't improve mood.

It's often a stimulant or a reuptake inhibitor, usually relating to dopamine in some way.

Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials.

Adderall, meanwhile, not only inhibits dopamine reuptake like Methylphenidate and Modafinil, but also enters the presynaptic terminals to exert effects within the cell.

D., is still deeply skeptical of some antidepressant medications (e.g., the selective serotonin reuptake inhibitors) because of their capacity for inducing mania in many bipolar patients.

It primarily works on norepinephrine as a reuptake inhibitor.

Modafinil's MOA is partially due to dopamine reuptake inhibition (similar to Ritalin), but Adderall relies largely on being taken in to the presynaptic terminals and forcing dopamine out.

I don't, and I see that I implied synthesis when I should have said that they only inhibit its reuptake, except for amphetamine, which also stimulates dopamine release.

The basic monoamine hypothesis has been known to be faulty for decades, nearly as long as monoamine reuptake inhibitors have been in widespread use; the psychiatric research community has long since been studying other possibilities.

Inhibiting the serotonin reuptake pump causes the serotonin to stick around longer in the synaptic cleft, which (again, roughly speaking) slows the serotonin dynamics down a bit and moves toward tonic, rather than phasic, signaling.