urate

Also it's a multi-species mutation that stuck in humans and the great apes which broke the urate oxidase enzyme.

Or you could just use rasburicase - recombinant urate-oxidase - instead.

Evolution isn’t stupid … it’s not a random outcome that we don’t produce our own vitamin c, or have an appendix, or (urate oxidize blah blah).

Wikipedia: > It has been proposed that the loss of urate oxidase gene expression has been advantageous to hominoids, since uric acid is a powerful antioxidant and scavenger of singlet oxygen and radicals.

Studies suggest that patients at a high risk of developing TLS may benefit from the administration of urate oxidase.[17] However, humans lack the subsequent enzyme HIU hydroxylase in the pathway to degrade uric acid to allantoin, so long-term urate oxidase therapy could potentially have harmful effects because of toxic effects of HIU.[18] > Higher uric acid levels have also been associated with epilepsy.

Gemini: > Therapeutically, recombinant urate oxidase (like rasburicase or pegylated urate oxidase) is used as a medication to rapidly lower uric acid levels, treating tumor lysis syndrome, hyperuricemia, and gout, especially when other treatments fail or are contraindicated.

A PEGylated form of urate oxidase, pegloticase, was FDA approved in 2010 for the treatment of chronic gout in adult patients refractory to "conventional therapy".[21] As a general rule though, you can effectively treat/prevent gout by significantly increasing consumption of water and by replacing proteins with cereal grains (or fruits and vegetables or vegetable fats).