glutathione

The damage is mediated by a secondary metabolite, of which about 10% of paracetamol goes through for secondary conjugation with glutathione which occurs really rapidly.

It is known that the cells of people with CF hoard both calcium and glutathione, a powerful antioxidant.

Fat soluble vitamins and even chemicals like Caffeine or even Glutathione are absorbed more eficiently when mixed with fat.

When considering NAC's mechanisms, it seems that it's efficacy is likely dependent on an individuals's glutathione status.

The interesting part is when the methylation process is disrupted by this mutation one of things whose production suffers is glutathione.

NAC is a precursor to the antioxidant glutathione, which the liver uses during step 2 of the alcohol metabolization process (acetaldehyde > acetic acid).

It targets glutamate excitotoxicity and as glycine + NAC + glutamate form glutathione, it also delivers both molecules needed to assemble it alongside glutamate.

> When considering NAC's mechanisms, it seems that it's efficacy is likely dependent on an individuals's glutathione status.

It seems to be safe overall and safe during pregnancy, and will prevent any potential depletion of glutathione stores which counteract the toxic metabolites of paracetamol.

(Tldr: you need to provide the building blocks for glutathione, which the liver uses a lot of.

NAC raises glutathione in serum and is extremely available.

His issues arose mostly as the result of his body's deficiency in creating glutathione, an essential antioxidant produced by our bodies to aid in the excretion of toxins.

Also the text says other studies supposedly shown decrease in lifespan in humans: "but the conclusion of this study was that supplementation with vitamin C depressed lifespan, probably by inhibiting production of the body’s native antioxidants, including glutathione and SOD=superoxide dismutase."