cholinergic

Unfortunately, you can't just enhance memory formation and learning related neurotransmission, you amplifiy cholinergic transmission indiscriminately everywhere.

Interestingly cholinergic drugs seem to do the opposite (increasing REM at the expense of slow wave sleep).

Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats.

People of West African descent occasionally (~10-20%, usually on the lower end of that) have a hypersalivatory response to cholinergic stimulation.

Now the bad news: Cholinergic neurotransmission is widespread through your brain and your body.

I have very weird reactions to cholinergic/anticholinergic drugs ranging from severe hallucinations to massive impacts to working memory.

This finding isn’t surprising given that cholinergic signaling has been known to be associated with depression for decades and many powerful antidepressants are anticholinergic.

But I've read a ton of studies about piracetam, and I've always had the impression that its primary mechanism was cholinergic.

Piracetam's primary mechanism of action is glutamatergic, not cholinergic.

For example, cholinergic drugs are known to provide symptomatic benefit in Alzheimer disease but not slow the underlying biological processes, so that worsening still continues at the same pace.

How many investigations on specific drugs were in fact showing mostly the results of what happens when interfering with one of the most ubiquitous-yet-underappreciated signalling systems, the cholinergic system?

The cholinergic impact is less pronounced.

>"We think the cholinergic (acetylcholine) signals that we know mediate this anti-inflammatory response aren't coming directly from the vagal nerve innervating the spleen, but from the mesothelial cells that form these connections to the spleen," O'Connor says.