acetylcholine

For instance, one might expect choline supplementation to increase the level of brain acetylcholine. It seems natural, right?

In particular, if you are trying to boost acetylcholine then CDP, PPC, and GPC have many fewer side effects than the re-uptake inhibitors like Huperzine. I agree with the comment on "restoring" vs."

Which can cause a significant excess of acetylcholine because they inhibit the down regulation process. You are correct that I was speculating what might cause "programmer burnout."

Donepezil is a cholinesterase inhibitor, meaning it increases the amount of acetylcholine circulating around nerve endings. They just casually put that there, but I don't think most readers will be exactly familiar with what that means?

Choline's positive effects on memory and the brain are very well known and increases in acetylcholine are one of the main methods of actions of nootropics in the racetam class. Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats.

The *racetams impact acetylcholine levels, and this neurochem plays a part in memory formation and retention. Additionally racetams are associated with increased oxygen flow in the brain.

The four "desires" driving all human behavior are: noradrenaline, acetylcholine, serotonin and dopamine.

Nicotine broadly matches up with acetylcholine and nicotonic acetylcholine receptors. It's far more likely that plants evolved and selected for compounds which have beneficial/detrimental effects on possible consumers, like nicotine as a pesticide, than it is that we have receptors for plants found in the wild on the off chance that we may have consumed them or that they would have been so prevalent in the past that receptors for them would have been selected for.

> Choline precursors don't seem to have these same "down-regulation" harmful side effects when taken in moderation to bring brain acetylcholine levels back into "normal range." "Don't seem"? Human studies needed. Maybe these already exist -- that would be handy. I'm not familiar with neurotransmitter supplementation. Taking something because you have a deficit is indeed different from trying to massively exceed your nominal levels. In the context of performance-enhancing mental drugs, exceeding your typical levels is of course the point of the exercise. > "programmer burnout" which likely involved depleted acetylcholine levels in the brain Possibly, but that assumption seems like it could be quite a leap.