mitochondrial

I am a physicist, and I'm interested in how mitochondrial function is measured and the efficiency is defined.

The researchers are in most circumstances looking at mitochondrial function (via oxygen consumption rates) rather than at mitochondrial DNA damage, which greatly muddies the water.

On the mechanistic side of things, it seems that fasting, among other things, cause a mild mitochondrial uncoupling[1].

There is also the mitochondrial DNA which is probably placed in the most unsafe environment inside the cell.

Hell depression and anxiety may even be mitochondrial disease manifestations in the brain in some cases.

For example, effects on mitochondrial function that lower their damage rate over time have been proposed as another activity for telomerase.

I think he was going for a take on mitochondrial Eve, and what could happen given current/future technology.

What is a mitochondrial uncoupler, and why would they help with neurological problems?

For the curious, another example of a mitochondrial uncoupler would be 2,4-dinitrophenol, which is currently being looked into as a potential anti-Alzheimer treatment[3].

In particular it seems to clean up damaged mitochondria, which is of considerable interest given the role of mitochondrial DNA damage in aging.

One open question is to whether it is secondary or primary mitochondrial disease.

Here's a simplified version: energy generation in the mitochondria is based on the energy differential between the intermembrane space and the inner mitochondrial membrane (I may have confused those membranes).

Those instructions were definitely not part of the "cell soup", as is shown by mitochondrial donation assisted reproduction technology (aka 'three-parent babies').

Note that I have a primary mitochondrial defect, so my nutritional experiments results are always "weird", for the lack of a better word.

And then, we should add the "length" of our mitochondrial DNA.

"God Particle", "Y-Chromosomal Adam", "Mitochondrial Eve"...

Mitochondrial DNA needs to be in the mitochondria, presumably because of proximity and/or latency issues.

Mitochondrial ancestors relieved those pressures in a couple ways.