folate

UV radiation breaks down folate (vitamin B9) in the bloodstream, and folate is critical for DNA synthesis and repair.

The folate you cited is definitely a concern given that folate and Vitamin D are factors in preventing birth defects.

This would mean they would increase their vitamin D, but reduces folate, and therefore increase the number of miscarriages?

Did the grain-eating D-deficient Baltic-dwellers have to do something else to restore the folate being lost by their lighter pigmentation?

All vegetables on the other side contain plenty of anti-nutrients such as folate and oxalates.

Slower THF regeneration impairs the folate cycle, increasing reliance on serine as a one-carbon donor.

Just the cheap folate only ones will do if you have a healthy diet.

You're also right that apart from the folate the losses are not so dramatic.

Just look at some historic numbers of the number of miscarriages with those diagnoses (these days pregnant women in Europe get folate supplements).

Their hypothesis is that skin color evolution as fundamentally about reproductive fitness: dark enough to protect folate, light enough to synthesize vitamin D.

I found the way the folate side of the equation was dropped midway through the article undermined the story a bit.

Also, women wanting to become pregnant should strongly consider folate supplements.

Folate deficiency causes serious problems in pregnancy, neural tube defects like spina bifida, and may impair sperm production.

It's a similar situation with Vitamin A, Vitamin C, Folic Acid vs Folate, etc.

Folate, folinic acid: those are safe to take, and pass through, for the entire population.