annonacin

And american paw paw fruits are full of annonacin and squamocin which are neurotoxic and cause pathology in humans.

The pawpaw fruit that has been eaten for generations contains annonacin, a neurotoxin.

Pawpaw fruit contains high concentrations of annonacin, which is toxic to nerve cells.

But I wonder about the possibility of producing varieties of pawpaw (or soursop or other related Annonas) that don't produce annonacin.

Contradictorily, consumption of soursop fruit is correlated with the development of neurodegenerative disease (Parkinson disease), which is attributed to the presence of annonacin in the seeds.

Missing mention of pawpaw's annonacin content, which causes Parkinsonism.

It is really good but it could also a dangerous thing to eat every day due to its annonacin (and related) content that can lead to neurotoxicity.

Downside; they all contain annonacin, which may cause Parkinsons.

I do see that it has annonacin which is also pretty bad if consumed regularly (hard to do with pawpaw) and something that pregnant women should probably avoid.

Breeders understanding how to breed for and against the annonacin content is actually very high on their list of priorities, not for eating, but the high annonacin makes pawpaws an excellent deer and mosquito repellent, and is being studied as a source for chemo-therapy and other drugs.

Annonacin toxicity is certainly a concern and effects of long-term exposure are not well understood, however the population from the most frequently cited study (namely, the well-known Guadeloupe study) also regularly consumed tea made from the leaves and bark of the tree which contain significantly more annonacin than the fruit -- in addition to eating several serving of the fruit nearly every day.

The author of the page you linked also seems to imply that their reaction was somehow specifically due to the annonacin, however I think a food allergy/intolerance is more likely (many people are allergic to citrus, or other tree fruit, for example).