(biochemistry) An allosteric modulator
Used in a Sentence
allosteric
Definitions, parts of speech, synonyms, and sentence examples for allosteric.
Editorial note
The quality of the data allows the determination of drug affinity, receptor type, receptor distribution, and allosteric interactions.
Examples8
Definitions2
Parts of speech2
Quick take
(biochemistry) An allosteric modulator
Meaning at a glance
The clearest senses and uses of allosteric gathered in one view.
(biochemistry, of an enzyme) That binds a compound on an inactive site and thus changes macromolecular conformation or dynamics in order to become either active or inactive
Definitions
Core meanings and parts of speech for allosteric.
noun
(biochemistry) An allosteric modulator
adjective
(biochemistry, of an enzyme) That binds a compound on an inactive site and thus changes macromolecular conformation or dynamics in order to become either active or inactive
Example sentences
The quality of the data allows the determination of drug affinity, receptor type, receptor distribution, and allosteric interactions.
Instead of directly causing dopamine release, it acts as an allosteric modulator on DAT to affect reuptake.
CBD, the second most prevalent cannabinoid, acts as a negative allosteric modulator at CB2.
Agonism, partial agonism, antagonism, inverse agonist, positive/negative allosteric modulation.
All I recall is that it was a positive allosteric modulator of the mu opioid receptor, which, by and large, may as well be Greek to me.
Our data confirm TrkB as a common primary target for antidepressants and suggest that high-affinity TrkB positive allosteric modulators lacking 5-HT2A activity may retain the antidepressant potential of psychedelics without hallucinogenic effects.
In addition to what you mention above, the authors could have tried to counter screen (much faster in silico!), find an allosteric inhibitor, identify a PPI/complex inhibitor, or take a leap by generating a SAR series in silico and validating a few selected compounds in vitro.
Quote examples
He chalked it up to "allosteric interactions".
Frequently asked questions
Short answers drawn from the clearest meanings and examples for this word.
How do you use allosteric in a sentence?
The quality of the data allows the determination of drug affinity, receptor type, receptor distribution, and allosteric interactions.
What does allosteric mean?
(biochemistry) An allosteric modulator
What part of speech is allosteric?
allosteric is commonly used as noun, adjective.