pepsin

I don't think so. Your pepsin can chemically separate it though.

This is just anecdotal, but I've had problems with heartburn for years and am having great succes with betaine hcl + pepsin supplements.

Generally, pepsin is used to treat the peptide chain without disconnecting the disulfide bond.

Something interesting: once acid escapes from the stomach into the esophagus, pepsin also escapes and lodges in your esophagus.

"Phytohaemagglutinin inhibits gastric acid but not pepsin secretion in conscious rats.

The major protective membrane glycoproteins, mucin, and lactadherin are resistant to conditions in the newborn's stomach and maintain their structure and function even at low pH and in the presence of the proteolytic enzyme pepsin.

After that I learned that pepsin is as bad or worse to your oesophagus than stomach acid.- cider vinegar: same result as betaine HCL + pepsin.- digestive enzymes: no change.- pro-biotics, including kefir: no change.- cutting gluten, dairy and sugar: no change.- ranitidine: works but effectiveness drops rapidly.- on-going experiments: liquorice and low-fodmap diet, no conclusions yet.

As someone who as been taking these for 3+ years and is utterly scared of these news I would just like to add a few data points regarding my experience that might help others:- an endoscopy revealed level 1 oseophagitis- triggers for me include: coffee, tea or any other source of caffeine, fried and high fat foods, alcohol, acidic fruits, high protein foods.- an experiment with betaine HCL + pepsin was very painful.