hydroxymitragynine

An interesting minor alkaloid of Kratom, 7-hydroxymitragynine, has been reported to be significantly more potent than morphine.

But there is a reasonable amount of other literature relating to kratom and its primary alkaloids, mitragynine and 7-hydroxymitragynine.

Chemical analysis of kratom shows that it contains 7-hydroxymitragynine, which is in fact an opiate several times stronger than morphine.

The active ingredient in Kratom however, 7-hydroxymitragynine, is absolutely an opiate and consequently a pain killer.

Animal testing shows that 7-hydroxymitragynine has opiod agonist activity 17-times greater than morphine.

One of them is 7-hydroxymitragynine which has agonistic effects on the mu-opiod receptors.

Moreover, what's the actual concentration of 7-hydroxymitragynine in the plant leaves?

One of these alkaloids is 7-hydroxymitragynine, in the same way that one of the alkaloids of coffee is caffeine and one of the alkaloids of coca is cocaine.

Milligram for milligram, 7-hydroxymitragynine is stronger than morphine.

> Chemical analysis of kratom shows that it contains 7-hydroxymitragynine, which is in fact an opiate several times stronger than morphine.

(Actually, in studies, mitragynine was shown to be 13x more potent than morphine, and 7-hydroxymitragynine to be 4x more potent than mitragynine, as per Vicknasingam et al 2010 in the International Journal of Drug Policy, and Matsumoto et al., 2005, Life Sciences).

From your link "Kratom contains over 50 alkaloids—primarily mitragynine and 7-hydroxymitragynine—which act as partial agonists at μ-opioid receptors"

> Opioids are substances that act on opioid receptors[1] From your link[2]: > The two main chemicals, mitragynine and 7-hydroxymitragynine, have strong activity at the main opioid receptor, the “mu” receptor, which is the same one stimulated by heroin and oxycodone.