methylcobalamin

The effects of supplements (primarily methylfolate and methylcobalamin) seems to depend on which mutation C677T, A1298, or both, and whether the person is homozygous or heterozygous.

Do doctors know most patients with resections or digestive issues who are B12 deficient can absorb methylcobalamin sublingually?

Related fun fact: the two types of B12 you typically find in stores are cyanocobalamin and methylcobalamin.

Unfortunately, methylcobalamin is often not preferred in injectable form due to very quick degradation into hydroxocobalamin upon exposure to light.

Subligual methylcobalamin works just as well as the shots and you can buy it anywhere.

For example cyanocobalamin and methylcobalamin are both vitamers of B12 despite being chemically distinct.

No idea if the long-term quiet environment played a role, but I also occasionally would supplement with sublingual b12[0] methylcobalamin supplements.

If someone would've told me methylcobalamin is a potent anti-depressant or some illegal drug I would've believed them based on the effects.

Some say the world should take cyanocobalamin, Some say methylcobalamin.

Yup, not everyone can convert cyanocobalamin or hydroxocobalamin to adenosyl-/methylcobalamin.

In the example I gave, methylcobalamin is superior when it comes to oral supplements.

How do methylcobalamin vs cyanocobalamin compare in this regard?

For a good example, look into "Vitamin B12" in methylcobalamin form vs.

Magnesium is known to be involved in "activating" riboflavin[1] into FMN, which then is involved in "activating" folate and B12 (and B6)[2][3] by transferring the methyl group back and forth to form methylfolate and methylcobalamin.

If one supplements cyanocobalamin, and one expects the body to convert it to methylcobalamin, and if this conversion doesn't happen for whatever reason, and if the measured form includes the inactive form, then "paradoxical B12 deficiency" can be observed.

I still take high potency B12 (Methylcobalamin) sublingually every morning.

B12 - Cyanocobalamine vs Methylcobalamin.