intrathecal

I'm a candidate for the intrathecal pain pump, which looks to be the only way the drug you mentioned can be administered.

Apparently fluconazole was not widely used at this point, and they treated her with Amphotericin B via intrathecal delivery, but the treatment was unsuccessful and she died.

Spine: intrathecal or systemic via AAV9 (eg.

Doctors can do intrathecal antifungal administration.

> requirement for chronic intrathecal dosing Well that's a pretty wicked drawback if I've ever heard one.

Many trials do NOT require patients to come in to take the medication, but there are of course some which are harder to take at home (whether intravenous or intrathecal or whatever).

TIL that, according to this paper, antisense treatment in the brain has some drawbacks: > Treatment of mice with antisense oligonucleotides (ASOs) targeting the Prnp transcript decreases expression of PrP and extends the survival of mice previously infected with misfolded PrP (6); however, the limited efficacy of ASOs and the requirement for chronic intrathecal dosing highlight the need for a more potent therapy.

It explicitly says that all of the tracer they used was cleared after 4 weeks: "After 4 weeks, there were no differences in normalized T1 signal as compared to before intrathecal CSF tracer administration in any of the groups (Supplementary Table 4), i.e.

Intrathecal administration typically uses an infusion pump to put drugs directly into the cerebrospinal fluid.

Intrathecal injections of a virus to splice in a functioning copy of the gene?