dehydrogenase

However, other drugs like fomepizole also inhibit alcohol dehydrogenase with lower toxicity than ethanol.

If a synthetic acetaldehyde dehydrogenase supplement could be scared-up (converts acetaldehyde into acetic acid) then hangovers could be a thing of the past.

It does work as a competitive inhibitor of alcohol dehydrogenase (i.e.

Alcohol dehydrogenase (and in alcoholics CYP2E1) breaks it down into acetaldehyde.

The ethanol competes with the methanol for the alcohol dehydrogenase enzyme, reducing the rate at which methanol is broken down in the body into really poisonous formic acid.

Aldehyde dehydrogenase breaks it down into acetone.

For someone with an actual, problematic addiction to alcohol, I don't know if the side-effects of an acetaldehyde dehydrogenase deficiency will be enough to stop drinking.

> Methods: This study investigates the role of SDR42E1, a gene encoding a short-chain dehydrogenase/reductase enzyme, in vitamin D regulation and sterol metabolism.

• It may cause hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

All measures of microbial activity were significantly greater in the organically farmed soils, including microbial respiration (33.3% more), dehydrogenase (112.3% more), acid phosphatase (98.9% more), and alkaline phosphatase (121.5% more).

Most of the effects of alcohol consumption that result in a hangover are caused by an accumulation of acetaldehyde[5] in the blood, the clearance of which is rate limited by an aldehyde dehydrogenase enzyme[6].

For all the bio-hackers looking to experiment tonight, it seems to make sense to: 1) take dry yeast to help the alcohol dehydrogenase break the alcohol down into acetaldehyde to stop you from feeling drunk 2) take both thiamine (optional) and cysteine to help the acetaldehyde dehydrogenase break acetaldehyde down into acetic acid to stop you from feeling hungover.

Eg, "The studies on human ADH (alcohol dehydrogenase) gene have suggested Darwinian positive selection on the genetic variation of ADH1B His47 [52–54].

It's worse for women who can't process ethanol ("alcohol") as well as men due to women's bodies producing less dehydrogenase which breaks down the ethanol.

In fact, we've evolved in order to process alcohol better: "The studies on human ADH (alcohol dehydrogenase) gene have suggested Darwinian positive selection on the genetic variation of ADH1B His47 [52–54].

"as with cyanide, the humans evolved with frequent exposure to small amounts of plant terpenes, …" I'm not a toxicologist but I know that a main function of the liver is to metabolize various toxins including those produced by one's body; eg, alcohol dehydrogenase enzymes mop up the small amounts of EtOH produced during digestion, same goes for numerous other 'nasties' including various terpenes.