centromere

I think what the article is trying to discuss is the ability to create doubled haploids using this other approach (the altered centromere).

But then you are seeing _two_ chromosomes that happen to be bound at a centromere before that centromere gets torn into two by the cytoskeleton dividing the cell in half.

There are also some fully wireless split keyboards like the southpaw centromere.

Even then the scientists knew that major parts of the centromere, telomere, and highly repetitive regions were not fully resolved, and that was fully admitted.

CHM13) Incidentally, they do capture the other chromosomes in this process: > Several chromosomes were captured in two contigs, broken only at the centromere (Fig 1a).

You sum up exactly the problem: the WSG technique does not give the whole global sequence of bases, from telomere to telomere through all of the centromere and for each chromosome branch.

To duplicate a human in computational space - say to create some accelerated AI simulation, you'd need to sequence a complete Telomere-to-Telomere genome (something achieved for the first time only last year!), complete Centromere sequencing (not yet achieved).

Their claim to sequence 100% of the genome could not be true if it was 100% DNA, as some locations like near the centromere or the telomeres are notoriousy difficult to sequence (and just impossible with the technique of alignment that they use).

Only a few gaps — 33 at last count — lie in or near each chromosome’s centromere (where the two parts of a chromosome connect) and telomeres (the caps at the end of chromosomes), but these 33 are 10 times as long in total as the 250 gaps.

Those "blank pages" weren't introns, they were the ends of the chromosomes (telomere) and the middle (centromere).

I got a wireless split keyboard "Centromere v2" and have had lots of issues with the connection.

I use an Ergodox-like keyboard (Centromere v2) and am currently typing on my laptop (normal Dell keyboard).

I can no longer type on my old Das, though, as I haven't used it ever since I got the Centromere.

I'm designing my won Centromere-alike right now, but I'll make it wired (and I'll print test layouts to see what fits my fingers better).