prion-like

The case is not for prions, but for prion-like behaviour in amyloid beta plaques.

That is, amyloid and tau (mis)conformation seems to be self-replicating via a prion-like mechanism in locally-connected regions.

It makes sense that some neurodegenerative diseases with unknown etiologies are caused by prions or prion-like proteins.

Alzheimer and other dementia are also probably the result of an a priori prion-like phenomenon.

The prion-like behavior mentioned is the ability of prions to do something similar.

Latest research was just so disheartening, as apparently ALS is a prion-like illness.

Alzheimer’s isn’t a prion disease, but it does show prion-like behavior.

I'm lacking expertise on the field, but how close is if there's mistake in the process that will produce a prion-like hazard?

Almost it's prion-like but it's not exclusively infectious or self-replicating.

Are we just ignoring the potential for totally novel forms of prion-like proteins?

My wife says the relevant scientific community were aware of prion-like domains early on in vaccine development and took this into account when designing the Moderna vaccine.

I expect that one day prion-like or viroid-ish molecules may well be found.

Moreover, a lot of related Alzheimer's research has come under intense scrutiny recently[0], so much so that the viral hypothesis of Alzheimer's is now dominant and no longer the "prion-like hypothesis", so, it's possible that the self-propagating protein fold is not the infectious agent for prion disease either.