nociceptive

So for most opioids, there's an adverse dynamic in which analgesic activity competes with nociceptive activity, leading to dose escalation.

Neural mechanisms of central sensitization modulate the amplitude of sensory inputs and enhance conscious perception of nociceptive and interoceptive stimuli.

Rather, nociceptive pathways might simply trigger some set of immediate, hard coded, higher level responses.

Actually nociceptive pain is by definition not in the brain and is fundamentally somatic.

As I'm modeling it, useful (evolutionarily) nociceptive pathways can give rise to avoidance or learning processes in any way whatsoever.

Perhaps non-inflammatory (or generically) nociceptive pain killing is the point.

In other words, employing nociceptive pathways to form a very basic set of associations between specific environmental conditions and some sort of danger or avoidance response.

That might sound like nitpicking but it's important because nociceptive responses can and do occur (and are of clinical significance) in patients who have lost consciousness.

One person's positive reinforcing experience is another's nociceptive hell.

Subjective emotion is a response to prediction on the nociceptive inputs we get.

An intrinsic salience to nociceptive signals, i.e.

Surely we benefit from being able to draw a distinction here?) So (for example) the mouse tail flick test is a means of quantifying the nociceptive response which presumably also causes the rodents some mild pain.

It absolutely is a "nociceptive hell" at first for everyone that tries it, but when you connect that with intention, purpose, and meaning it eventually transforms into something almost enjoyable.

These nonneuropathic pain entities are said to be nociceptive and include conditions such as osteoarthitis and inflammatory pain." Now to put it in layman's terms from a patient that doesn't understand the medical condition (me); the pain comes from my nerves/brain not working right.

“As pain becomes chronic, it is increasingly associated with activity in the affective and motivational systems tied to avoidance and less closely tied to systems encoding nociceptive input” [1] I’ve been on the slippery slope of chronic pain.

I don't think the most charitable view is that species "deserve to suffer." It's that they have different capacities for suffering, and that differences in the complexity of the nociceptive and the nervous systems are inputs into our understanding when we try to figure this stuff out.