lymphatics

However, there been work in injecting radioimmunoagent tracers into lymphatics especially in the case of melanomas.

Actually, UVA is where they found evidence of lymphatics bridging from the meninges, so this likely a related group carrying out experiments they were able to start in advance of the lymphatics publication because, neighbors.

Without lymphatics, fluid would build up in body tissues, and there would be no way to alert the adaptive immune system to invading pathogens.

Intracellular adenosine which builds up over the course of waking day may be uptaken by brain lymphatics but would play a small part if they are inside the dura as this states.

Without lymphatics, fluid would build up in body tissues, and there would be no way to alert the adaptive immune system to invading pathogens sift/scan/alert/invade I always find it interesting how much agency we assign these systems when we describe them.

So, while the circulation and absorption of cerebrospinal fluid is very important, I am not sure how much these lymphatics translate from mice to humans, and it is not like doctors are not aware of and don't have treatments for too much cerebrospinal fluid.

The likely reason why these haven't before detected these meningeal lymphatic vessels is likely because: (1) We don't bother imaging the brain because "the brain doesn't have lymphatics" and (2) tracers generally flow with the direction of fluid and the direction of lympth from the CNS is likely efferent rather than afferent.

Also interesting is this: "researchers were able to successfully modulate cervical lymphatics using phenylephrine (which activates α1-adrenergic receptors, causing smooth-muscle contraction)" Phenylephrine is the so-called decongestant that has finally been called out for being a fraud in oral medications (and I can tell you from painful, painful experience that it is indeed a fraud).