hydroxy-mitragynine

Synthesize 7-hydroxy-mitragynine and get it approved by the FDA for the treatment of severe chronic pain.

The patent holder for formulations of 7-hydroxy-mitragynine would need to be much more responsible about marketing than the Oxycontin suppliers.

The active alkaloid, 6-hydroxy-mitragynine is 30 times more powerful than morphine by weight.

The percentage content of the active alkaloids in Kratom (Mitragynine and 7-Hydroxy-Mitragynine) can vary widely, with the stuff sold in gas stations and smoke shops being particularly low-potency or volatile.

This study is on a guinea pig, where they didn't get the 17x number but concluded that 7-hydroxy-mitragynine is a dose dependant antinociceptive that is stronger than morphine.[3] They do a follow up study demonstrating cross tolerance with morphine.

Then shortly after it comes out that GlaxoSmithKline, who the FDA head (Scott Gottlieb) at the time of the attempted ban sat on the board for just a year prior, was trying to bring synthetic 7-hydroxy-mitragynine (7hm is thought to be a main active ingredient in kratom) to market, which it has a patent on.