aligners

Certainly it's not impossible to DIY, but it's more difficult than just popping some aligners on your 3d printer.

Failure mode: good treatment plans are rarely possible or output is garbage (aligners do not fit, cause pain etc) 4.

Dentistry has already been slowly shifting that direction for years with better materials, scanners, and aligners.

Couldn't you use one of the available short read aligners (BWA,bowtie...) available for this also?

Many sequence assemblers/aligners use variants of FM-indexes and Compressed Suffix Arrays, that are self-indexes based on the Burrows-Wheeler Transform and Wavelet Trees.

Failure mode: bad scan leads to aligners not fitting your teeth from day 1.

Yes, aligners and retainers in theory may be printed on some commercially available hardware.

Most of the aligners use some kind of FM-index for indexing the genome.

Also who’s attaching the attachments (I had 13 at first) to the teeth to help the aligners grab hold?

US no longer sole superpower, when it tries to insist upon itself, current aligners are seeing limitations of power and cost of alignment.

I'm a heavy user, but not a developer of aligners (except a toy one).

But as for matching both speed and accuracy of state-of-the-art aligners with Javascript, it is my considered, scholarly opinion that you have no chance in hell.

My colleague (an editor at Bioinformatics journal) and I were joking the other day about how every other paper title, especially about aligners, seems to include the word "fast" in it.

Aligners may become more accessible to patients, because that tech is more scalable by design.

Aligners do not need that - they may need a check-up in the middle of the treatment, maybe one or two mid-course corrections, maybe an appointment for installation of attachments, but that's it.