homozygotes

This is an important genetic profile for those who understand Alzheimer’s, as homozygotes for APOe4 are 12x more likely to develop Alzheimer’s.

It's the same allele, of course, heterozygotes get the benefit, homozygotes get the disease.

For example homozygotes for M129 have a much faster rate of vCJD development.

Individuals who are rs762551(A;C) heterozygotes or rs762551(C;C) homozygotes are both considered slow metabolizers.

Just avoiding homozygotes for any rare genetic variant you don't have flagged in your database as well-understood will go a long way to avoiding in-breeding issues.

Some of these optimized results have been astounding, often with no detectable off-site modifications, and 100% efficiency (no need to wait for the T2s for homozygotes)!

On the other hand, in a sexually reproducing organism, a disadvantageous mutation can be masked if recessive, and selective pressure will only remove homozygotes from the population.

[snip] > In both the Ashkenazi and Sephardi Jewish communities, there is an increased rate of a number of genetic disorders such as Tay–Sachs disease, an autosomal recessive disorder that goes unnoticed in carriers, but is fatal within the first few years of life in almost all homozygotes.