bradykinin

There was some discussion that it is a bradykinin storm, not a cytokine storm.

Thus, degrading bradykinin via ACE is a good way to improve your breathing.

Hmm - that strikes me as kind of roundabout - why they couldn't just measure bradykinine levels directly?

Again, this could stop potentially deadly bradykinin storms from forming.

> why they couldn't just measure bradykinine levels directly?

Maybe, I found out a study[1] that suggest that nicotine helps in the vascular metabolism of bradykinin.

Her latest diagnosis from a cardiologist is PoTS - but it could well be the bradykinin issues causing very similar symptoms.

The farther along the path of inference, the weaker the conclusions get, but it sounds like a promising arrow for research to me.> why they couldn't just measure bradykinine levels directly?

They found out that some genes related to ACE in comparison to genes related to ACE2 are more 'expressed' in Covid patients than normally and they conclude that that must have resulted in too much bradykinine.

If indeed the vitamin proves effective at reducing the severity of bradykinin storms, it could be an easy, relatively safe way to reduce the severity of the virus.

Derek Lowe wrote a post this week on the "bradykinin hypothesis," and how it has been gaining traction as a unifying model that can explain many of the observed effects of infection, including sensitivity to vitamin D levels.

... This very atypical pattern of the RAS is predicted to elevate bradykinin levels in multiple tissues and systems that will likely cause increases in vascular dilation, vascular permeability and hypotension.

This very atypical pattern of the RAS is predicted to elevate bradykinin levels in multiple tissues and systems that will likely cause increases in vascular dilation, vascular permeability and hypotension.

We don’t know the dosage or protocol for stopping the bradykinin storm, or even if this hypothesis is confirmed through more tests ... but it seems sensible to me to make sure one has a healthy level of Vitamin D, and that is actionable for a lot of people.